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[177Lu]Lu-DOTA-STR-17126

Development stage: Phase 1
Lead developer: Integrated Haematology and Oncology Network
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

[177Lu]Lu-DOTA-STR-17126 is a radiopharmaceutical candidate being developed as part of a theranostic pair for the management of advanced or metastatic cancers, specifically breast and prostate cancer. It consists of the radionuclide lutetium-177 (177Lu) complexed with the DOTA-STR-17126 precursor, which targets the gastrin-releasing peptide receptor (GRPR). GRPR is frequently overexpressed in various malignancies, including prostate and breast cancers. In the context of the Phase 0 exploratory study, a low dose of [177Lu]Lu-DOTA-STR-17126 is used for SPECT imaging and radiation dosimetry to evaluate the biodistribution and pharmacokinetics of the tracer, following initial PET imaging with its gallium-68 labeled counterpart, [68Ga]Ga-DOTA-STR-17126.

Other names: 177Lu-DOTA-STR-17126

Targets

GRPR (Gastrin-releasing peptide receptor)

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